Duomo / Piazza della Signoria
The neighborhood that surrounds the Duomo constitutes the very heart of the historical city center and the area has probably one of the highest concentrations of art per square meter on the whole planet: churches, statues, museums, towers, and historical buildings fill every corner of every street. You can't miss Brunelleschi's magnificent dome atop the rosy marble Cathedral.
If you stay here, you're in the vicinity of practically everything: the Uffizi Museums, Palazzo della Signoria, Palazzo Davanzati, Galleria dell’Accademia, Ponte Vecchio. If you are in need of a break after wondering around this architectural and artistic marvels, you can recharge your batteries at one of the cafés on nearby Piazza della Repubblica.
The streets surrounding the Duomo cater to visitors, with fine dining and exclusive shopping. The top Italian fashion houses are located along Via Tornabuoni , with several others on Via Calzaiuoli and Via del Corso. Souvenir shops abound, as do street performers and caricature artists.
This area is, understandably, the central meeting point and the tourist hub of the city. Probably at night, when the tourist groups disappear, you can better appreciate the magical atmosphere of the most romantic heart of pre-Renaissance Florence.